I've put up a few posts over the past month about some of the leaders in the upcoming Civilization VI. As with any PC game there are some specs that need to be met if you even want the chance to run your own civilization, and 2K has posted the minimum and recommended specs to run Civilization VI.
For starters, they have the listed OS being Windows 7, 8.1, or 10, but they also list each as 64 bit, so if you're still running a 32 bit system, you might be out of luck. Either an Intel Core i3 or an AMD Phenom II is required as is 4 GB of RAM, 12 GB of hard drive space, and a 1 GB DX 11 video card which they listed either an AMD 5570 or an NVIDIA 450. Not too terribly bad as I'm sure a lot of gamers probably have most of this already covered.