I'm sort of surprised that this didn't happen sooner but it looks like a group of folks are looking to remake Duke Nukem 3D
using the Unreal engine. They even have some screenshots of parts of levels they have done and they do look pretty good.
The team's got the blessing from Gearbox so there's not going to be any legal hurdles to overcome. The question is if a group of guys working for free and in their spare time can get the game out at all. I wish them luck but it's not unprecedented for a fan remake to be done and done well.
It would be funny though if it took 10+ years for the remake to come out.