It looks like CD Projekt got a lot out of Mass Effect 2
as The Witcher 2
is going along the same route in a few ways according to the latest developer diary. The game will be a completely self-contained story but you will be able to import your character from the first game if you so choose. Doing so will have implications though as the decisions you made in the first Witcher game will now come back to haunt you.
The game will also be a much more focused experience with the developers de-emphasizing FedExt style missions in the game. There's a lot more tucked into the six minute developer diary so be sure to check it out if you're looking for a good RPG for later this year.